Steady State Concentration

e- Absorption rate constant

Examine the conc-time profiles if the same dose of a drug is administered using different products that have different rates of absorption (all other parameters are constant)

Parameters
D (mg) F CLT(L/hr) Vd (L) ka (hr-1)
1000 1 2.5 25 1.0
ka

The absorption rate constant does not affect the average steady state conc, however slower rate of absorption results in less fluctuations in the steady state conc.

ka