Steady State Concentration

d- Volume of distribution

Examine the conc-time profiles after administration of the same dose of different drugs that have different Vd (all other parameters are constant).


OR

Examine the conc-time profiles after administration of the same dose of the same drug to different individuals who have different body weights (individuals with different Vd).

Parameters
D (mg) F CLΤ(L/hr) Vd (L) ka (hr-1)
1000 1 5 25 0.3
Vd (L)

The volume of distribution dose not affect the steady state conc. The steady state conc is only dependent on the CLΤ and the dosing rate (FD/τ).