Causes of nonlinear pharmacokinetics

1- Saturable drug absorption

Drugs that are absorbed by saturable transport system in the GIT or undergo saturable first-pass effect have dose-dependent bioavailability.

2- Saturable protein binding

Drugs that undergo saturable plasma protein binding or saturable tissue binding, have conc-dependent distribution characteristics. Also, saturable protein binding can affect drug elimination since the rate of drug elimination is dependent on the free drug conc (specially for low extraction ratio drugs).

3- Saturable renal elimination

Drugs that are actively reabsorbed or actively secreted in the renal tubules undergo dose-dependent renal elimination after administration of large doses.

4- Saturable drug metabolism

Drugs that are metabolized by a saturable metabolic pathway exhibit dose-dependent pharmacokinetics after administration of large doses.

5- Others

Other conditions such as enzyme induction, product inhibition, and drug-related pathological changes that affect drug excretion can result in nonlinear pharmacokinetics.

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