Characteristics of linear pharmacokinetics:

1- Linear plasma conc-time profile during the elimination phase on semilog scale.

2- Proportional increase in AUC with the increase in dose.

3- Proportional increase in steady state conc with the increase in dosing rate during multiple drug administration.

4- Pharmacokinetic parameters such as half life, total body clearance and Vd do not change with the increase in dose.

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