Example: Several acetaminophen oral products which differ only in the rate of drug release and the rate of drug absorption are available in the market. The absorption rate constant for four different products are 0.35, 0.6, 1.0, and 1.8 hr-1, respectively. Which product would you recommend for rapid treatment of headache ?

(The other acetaminophen parameters are k= 0.3 hr-1, F = 1, and Vd is 1L/kg).

Absorption rate constant (hr-1)

Faster drug absorption results in faster onset of effect. The product with the fastest rate of absorption is the most appropriate for the rapid treatment of headache.

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