Plasma conc-time profile after oral
drug administration (cont'd)

e- Absorption rate constant

Examine the conc-time profiles if the same dose of a drug is administered using different products that have different rates of absorption (all other parameters are constant).

Parameters
D (mg) F CLΤ(L/hr) Vd (L) ka (hr-1)
1000 1 2.5 25 1.0
ka

Larger absorption rate constant results in faster drug absorption.
The change in the absorption rate constant does not affect CLT, Vd, F, AUC, and k.

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