Questions

Module10-Oral drug administration
Objectives
Introduction
Plot
- Plot
- Linear
- Semilog
- Help
Questions

Module
10-Oral drug administration

Introduction to pharmacokinetics
IV administration
Oral administration
Steady state concept
- Constant rate infusion
- Multiple Drug Administration
Drug elimination
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
- Two compartment pharmacokinetic model (I)
- Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring

Objective
Introduction

Introduction
Determination of the pharmacokinetic parameters
Factors affecting the drug concentration-time profile
- Dose
- Bioavailability
- Total body clearance
- Volume of distribution
- Absorption rate constant
Summary

Plot

Plot
Linear
Semilog
Help

Questions

The Wagner-Nelson method was used to determine the absorption rate constant of ciprofloxacin. A plot of the fraction of the dose remaining to be absorbed versus time was linear on a semilog scale and had a slope of -0.72 hr-1. Calculate the absorption rate constant for this drug.

1 - 1.66 hr-1 2 - 0.96 hr-1 3 - 3.2 hr-1 4 - 0.30 hr-1 5 - 1.66 hr-1 6 - 0.96 hr-1 7 - 3.2 hr-1 8 - 0.30 hr-1 9 - 1.66 hr-1 10 - 0.96 hr-1 11 - 3.2 hr-1 12 - 0.30 hr-1 13 - 1.66 hr-1 14 - 0.96 hr-1 15 - 3.2 hr-1 16 - 0.30 hr-1

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