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Module10-Oral drug administration
Objectives
Introduction
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Module
10-Oral drug administration

Introduction to pharmacokinetics
IV administration
Oral administration
Steady state concept
- Constant rate infusion
- Multiple Drug Administration
Drug elimination
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
- Two compartment pharmacokinetic model (I)
- Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring

Objective
Introduction

Introduction
Determination of the pharmacokinetic parameters
Factors affecting the drug concentration-time profile
- Dose
- Bioavailability
- Total body clearance
- Volume of distribution
- Absorption rate constant
Summary

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Questions

Zidovudine is an antiviral drug that inhibits HIV replication. The oral bioavailability of zidovudine is 70 % and its total body clearance is 1.2 L/hr/kg. What will be the expected AUC after administration of a single oral dose of 6 mg/kg zidovudine ?

1 - 3.5 mg-hr/L 2 - 5.0 mg-hr/L 3 - 4.2 mg-hr/L 4 - 0.84 mg-hr/L 5 - 3.5 mg-hr/L 6 - 5.0 mg-hr/L 7 - 4.2 mg-hr/L 8 - 0.84 mg-hr/L 9 - 3.5 mg-hr/L 10 - 5.0 mg-hr/L 11 - 4.2 mg-hr/L 12 - 0.84 mg-hr/L 13 - 3.5 mg-hr/L 14 - 5.0 mg-hr/L 15 - 4.2 mg-hr/L 16 - 0.84 mg-hr/L

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