Factors Affecting the Plasma Conc-Time
Profile after Oral Drug Administration

a- Dose

Examine the conc-time profiles after administration of different doses, while keeping all other parameters constant.

Parameters
D (mg) F CLΤ(L/hr) Vd (L) ka (hr-1)
1000 1 7.5 50 0.5
Dose (mg)

Higher doses produce proportional increase in the AUC without affecting CLT, Vd, and k (first-order elimination).

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