Note that the same drug can have different Vd in individuals with different body weights. Administration of the same dose of a drug to individuals with different Vd will produce different drug cone depending on Vd and CLT.
Larger Vd results in slower rate of drug elimination without affecting the AUC (when the CLT is constant).
kais the first-order absorpation rate constant (time-1).
Volume of distribution
The volume of distribution is the apparent volume in which the drug can distributed in. It is the parameter that relates the amount of drug in the body to the concentration of the drug in the sampling site. It is not an actual volume, however it is a hypothetical volume determined by the drug distribution behavior.
The volume of distribution ranges from 3-5 liters to more than 25 L/kg. Drugs with higher affinity for tissues, have higher volume of distribution.
