Plasma Conc-Time Profile after Oral
Drug Administration (cont'd)

c- Total body clearance

Examine the conc-time profiles after administration of the same dose of different drugs that have different CLT (all other parameters are constant).

Parameters
D (mg) F CLΤ(L/hr) Vd (L) ka (hr-1)
1000 1 3.5 50 0.3
CLT (L/hr)

Higher CLT results in faster rate of drug elimination (if Vd is the same).
After administration of the same dose, drugs with higher CLT will have lower AUC.

  • Page 1 of 2
  • 1
  • 2