Pharmacodynamic models

3- The Emax model

E =

Emax C

EC50 + C
Emax

1

2E max
EC50

The model parameters (Emax and EC50) can be estimated by fitting the drug conc and effect data to the equation that describes the model.

Emax is a measure of the intrinsic activity of the drug, i.e. the maximum effect that can be achieved by the drug.

EC50 is a measure of the drug potency. Drugs with lower EC50 are more potent than drugs with higher EC50, when Emax is similar.

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