Pharmacodynamic models

4- The sigmoid Emax model

This model is similar to the Emax model, however it can be applied when the conc-effect relationship does not follow the typical simple hyperbolic function.

E =

Emax Cn

ECn50 + Cn

" n " is the parameter that affects the shape of the curve. When n>1, this means that the interaction of the first molecule with the site of action makes the site of action more sensitive to the interaction with the following molecule.

When n<1, this means that the interaction of the first molecule with the site of action makes the site of action less sensitive to the interaction with the following molecule.

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