Pharmacodynamic models

1- The linear model

This model assumes a linear relationship between the drug concentration at the site of action and the observed effect over a certain range of drug concentrations.

E = S C
slope=S

This model assumes that there is no effect in absence of the drug (conc=0). If the measured effect has some value in absence of the drug (for example blood pressure), the model can be expressed as:

E = E0 + S C
slope=S E0
If a linear relationship exists between the
drug conc and the effect, linear regression
can be performed to estimate the model
parameter(s): the slope (S) and baseline
effect (Eo )

The slope is the model parameter that determines the change in drug effect due to the change in drug conc. The slope is a measure of the potency of the drug.

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