Objectives

After Completing this module you should be able to:

• Describe the different pharmacodynamic models that can relate the drug concentration at the site of action and the direct pharmacological effect.

• Describe how the pharmacokinetic models can be linked to the pharmacodynamic models to predict the time course of the drug pharmacological effects.

• Utilize the pharmacokinetic/pharmacodynamic principles to determine the duration of drug effect when the drug effect is dependent on the plasma drug concentration.