Pharmacokinetic/Pharmacodynamic Model
Dose : The administered dose, mg
F : The drug bioavailability, unitless
Dosing interval : The time between doses, hours
ka : The first order absorption rate constant, hour -1
Vd : The volume of distribution, liters
k (CLT/Vd) : The first order elimination rate constant, hour -1
E : is the intensity of the effect
Emax : is the maximum effect
n : is the sigmoidicity factor. (Unitless).
EC50 : is the drug conc when the effect is 50% of the maximum effect (amount/volume)
C : is the drug concentration at the site of action, the plasma (amount/volume)