The drug conc-time profile and drug effect-time profile after multiple oral doses.

0

F Dose = 0 mg

2000

0

Dosing Interval = 0 hr

24

3

Vd = 3 liters

200

0

ka = 0 hr-1

3

0.1

CLT = .1 L/hr

50

t1/2 = hr

0 %

Emax = 0 %

400

0

EC50 = 0 mg/L

100

0

n = 0

4

Definition of parameters

The bioavailable dose of the drug.

The dosing interval

volume of distribution

The first-order absorption rate constant

The total body clearance and the half life

The maximum drug effect

The drug concentration which produces 50% of the maximum drug effect

The sigmoidicity factor.

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