Dose : The administered dose, mg

F : The drug bioavailability, no units

Dosing interval : The time between doses, hours

ka : The first order absorption rate constant, hour-1

Vd : The vloume of distribution, liters

k : The first order elimination rate constant, hour-1

Dose : The administered dose, mg

F : The drug bioavailability, no units

Dosing interval : The time between doses, hours

ka : The first order absorption rate constant, hour-1

Vd : The vloume of distribution, liters

k : The first order elimination rate constant, hour-1

Select values for the different PK and PD parameters by dragging the slider for each parameter on the right. The current parameter value will be displayed.

The drug concentration-time profile and the drug effect-time profile will be graphed when you click plot.

You can change the time scale, conc scale, and effect scale values by clicking the adjust scale buttons

Enter the maximum value for the X axis. The minimum value for the X axis will be zero.

Enter the maximum value for the Y axis. The minimum value for the Y axis will be zero.

Enter the maximum value for the effect scale. The minimum value for the effect axis will be zero.