The increase in hepatic blood flow decreases the extraction ratio. Since CL_H = Q E, the overall effect will be very small increase in the hepatic clearance, and total body clearance.

The decrease in extraction ratio will increase the bioavailability, but this will not have a significant effect on the plasma conc-time profile. The decrease in extraction ratio from 0.1 to 0.05 will increase the bioavailability from 0.9 to 0.95. This will not affect the plasma conc-time profile significantly.