The increase in liver blood flow results in a slight decrease in extraction ratio, but the overall effect will be an increase in the hepatic clearance, and total body clearance.

The small decrease in extraction ratio will cause a proportional increase in drug bioavailability. This change in bioavailability will have a significant effect on the drug conc-time profile. The decrease in the AUC because of the increase in total body clearance will be compensated by the increase in AUC due to the higher bioavailability.