After iv administration of 500 mg procainamide to a patient, the plasma concentration-time profile can be described by the following equation:

Cp= 5 e^{- 0.2 t}

What is the total body clearance of procainamide in this patient ?

k = 0.2hr ^-1

Vd =

Dose

Cp₀

Vd =

500mg

5 mg/L = 100L

CL_T =0.2 hr ^-1 X 100 L = 20 L/hr