Plasma conc-time profile after a single oral dose

The equation that describes the plasma drug concentration-time profile after a single oral dose can be obtained by dividing the equation for the drug amount by the volume of distribution (Vd).

Cp =

F D ka

Vd (K a - k)
( e -kt - e -ka t)

tmax

Cpmax

Cpmax is the maximum (highest) plasma drug concentration achieved after oral administration.

tmax (the time to achieve Cpmax) depends on k and ka and can be calculated as:

tmax =

In ka - In k

ka - k

and Cpmax can be determined by:

Cpmax =

F D ka

Vd (ka - k)
(e -k tmax - e-ka tmax)
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