When is larger that the absorption process will be faster than the elimination process and the terminal phase of the concentration-time profile will represent the elimination process.
ka > k
drug elimination
drug absorption
Applying the method of residuals, the residuals versus time plot will represent the absorption process.
However, when drug absorption is slower than drug elimination, the terminal phase of the conc-time profile will represent the slower process (drug absorption).
k > ka
drug absorption
drug elimination
The residuals versus time plot will represent the elimination process.
This behavior is known as flip flop of and .
