Objectives

After completing this module you should be able to:

• Describe the mechanisms of drug absorption after oral administration.

• Describe how the rate and the extent of drug absorption after oral administration affect the onset and the duration of drug effect.

• Calculate the drug half-life after oral administration.

• Analyze how the change in the absorption rate constant affects the plasma concentration-time profile after a single oral administration.

• Determine the absorption rate constant utilizing the method of residuals.

• Determine the absorption rate constant using the Wagner-Nelson method.