Calculation Of AUC

after iv drug administration

AUC t= ∞t=0 =

Cp0

k

a- Plot the plasma concentrations determined after administration of an iv dose of the drug on a semilog scale.

Cp0

t1/2

k =

0.639

t1/2
Slope = -k/2.303

b- Draw the best line that goes through the samples.

c- Determine the elimination rate constant (k) from the slope of the line, or from the half life of the drug.

d- The Y-intercept is the plasma concentration at time zero (Cp0).

AUC t= ∞t=0 =

Cp0

k
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