Calculation of AUC

The trapezoidal rule:

The idea is to divide the plasma concentration-time profile to several trapezoids, and calculate the AUC by adding the areas of these trapezoids.

a- Plot the plasma concentrations measured after administration an iv dose of the drug.

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b- Connect the plasma samples by straight lines, and divide the plasma profile to trapezoids.

c- AUC = area of trapezoid 1 +
area of trapezoid 2 +
area of trapezoid 3 +
....etc.

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