Questions

Smokers are known to have approximately 50% higher theophylline clearance compared to nonsmokers. If the average theophylline AUC observed after iv administration of 300 mg of theophylline in nonsmokers is 100 mg-hr/L, what is the expected theophylline AUC in smokers after administration of the same dose (300 mg theophylline iv) ?

1 - 300 mg-hr/L 2 - 100 mg-hr/L 3 - 75 mg-hr/L 4 - 3 mg-hr/L