The effect of dose on AUC

AUC t= ∞t=0 =

Dose

CLT

The AUC is directly proportional to the administered dose when drug elimination follows first order kinetics (linear pharmacokinetics).

Administration of different doses of a drug to the same subject (the same total body clearance.) produces AUCs that are proportional to the administered dose.

Dose (mg)

CLT = 2 L/hr

The AUC is proportional to the administered iv dose

  • Page 1 of 2
  • 1
  • 2