Pharmacokinetic Model

Iv bolus

(Dose)

Systemic Circulation

(Vd)

k

  • Dose : The administered dose, mg

  • Vd : The volume of distribution, liters

  • k : The first order elimination rate constant, hour -1

AUC =

Dose

CLT

CLT

Vd
= k

Choose different values for the dose and the total body clearance, then simulate the corresponding drug concentration-time profile.