Trapezoidal rule (cont'd)

Cp1 , t1
1
Cp2 , t2
2
Cp3 , t3
3
Cp4 , t4
4
Cp5 , t5
tail

Area of:

Trapezoid 1 =

(Cp1 + Cp2)

2
.(t2 - t1)
Trapezoid 2 =

(Cp2 + Cp3)

2
.(t3 - t2)
Trapezoid 3 =

(Cp3 + Cp4)

2
.(t4 - t3)
Trapezoid 4 =

(Cp4 + Cp5)

2
.(t5 - t4)

Area of last trapezoid or area under the tail of the curve

=

last concentration

k
=

Cp5

k

AUC = total area of all trapezoids

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