After iv administration of drugs, the distribution to some tissues may be much slower than the distribution to other tissues. In this case the drug profile will consists of a biexponential distribution phase followed by a terminal elimination phase.
Pharmacokinetics Model
Deep Peripheral
compartment
The plasma conc-time profile will be described by a triexponential expression:
The plasma conc-time profile consists of three distinct phases. These include a rapid distribution phase, a distribution phase and a terminal elimination phase.
Rapid
distribution
Distribution
Elimination
