Objectives

After completing this module you should be able to:

• Describe the plasma concentration-time profile after a single oral administration of drugs that follow two-compartment pharmacokinetic model.

• Describe the plasma concentration-time profile during constant rate iv infusion of drugs that follow two-compartment pharmacokinetic model.

• Describe the plasma concentration-time profile during multiple administration of drugs that follow two-compartment pharmacokinetic model.

• Determine the renal excretion rate and the renal clearance of drugs that follow two-compartment pharmacokinetic model.

• Analyze how the pharmacokinetic parameters affect the drug distribution between the central and the peripheral compartments after a single and multiple administration of drugs that follow two-compartment pharmacokinetic model.