a- The two-compartment model used in our discussion assumes distribution between the central and peripheral compartments and first-order drug elimination from the central compartment.
b- It is possible that the drug is eliminated only from the peripheral compartment.
c- It is possible that the drug is eliminated from the central and the peripheral compartments.
These three models are two-compartment pharmacokinetic models.
The plasma conc-time profile after iv administration of drugs that follow these models will be similar and have a distribution phase and an elimination phase.
However, the relationship between the model parameters will be different in these three models.
