Dose :  The administered dose, mg

Dosing interval :  The time between doses, hours

V_c :  The volume of distribution of the central compartment, liters

k₁₂ :  The first order transfer rate constant from the central to the peripheral compartment, hour ^-1

k₂₁ :  The first order transfer rate constant from the peripheral to the central compartment, hour ^-1

k₁₀ :  The first order elimination rate constant from the central compartment, hour ^-1