Multiple drug administration

Drugs that follow two-compartment model accumulate during multiple administration until a steady state is achieved.

Cpmin ss
Cpmax ss

Although the plasma conc will be changing within each dosing interval, the maximum and the minimum plasma concentrations will be constant at steady state.

The average plasma conc at steady state is:

Cpss average=

Dose

CLT τ

For multiple oral drug administration :

Cpss average=

F Dose

CLT τ

These relationships are similar for one- and two-compartment models.

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