Since the amount of drug in the central compartment declines biexponentially after a single iv dose, the renal excretion rate versus time plot declines biexponentially.
Slope = -β/2.303
β t1/2
The renal excretion rate versus time plot includes a distribution phase and an elimination phase.
The hybrid elimination rate constant can be determined from the terminal phase of the renal excretion rate-time profile.
The hybrid distribution rate constant can be determined utilizing the method of residuals.
