Oral administration of drugs that
follow two-compartment model

The drug has to be absorbed from the site of administration in order to reach the systemic circulation. Once in the systemic circulation, the drug can be distributed to the peripheral compartment and can be eliminated from the body.

Pharmacokinetic Model

Peripheral
compartment

k21

k12

GIT

ka

Central
compartment

k10

The rate of drug absorption is dependent on the first-order absorption rate constant, ka.

The rate of distribution and elimination are dependent on the hybrid rate constants α, and β similar to iv drug administration.

The plasma conc-time profile can be described by a triexponential equation that describes the rate of absorption, distribution and elimination.

The drug bioavailability will affect the drug AUC similar to the drugs that follow one-compartment pharmacokinetic model.

AUC =

F Dose

CLT
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