Time to steady state

The time to achieve steady state of drugs that follow two-compartment model, is dependent on the elimination half life. It takes 5 - 6 elimination half lives (β t1/2) to achieve steady state.

Beta Half Life (hr)
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Drugs with longer elimination half life require longer time to reach steady state.

When the same drug is administered by different infusion rates, the steady state concentrations will be proportional to the infusion rate. However the time to reach steady state is independent of the infusion rate.

inf. rate (mg/hr)
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S.S.
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