Example: The following concentrations were obtained after administration of a single 500 mg oral dose of an antibiotic (F=1):
| Time (hr) |
Conc (mg/L) |
Time |
Conc |
| 0.5 |
3.5 |
4.0 |
8.1 |
| 1.0 |
5.8 |
6.0 |
6.3 |
| 2.0 |
8.1 |
9.0 |
3.2 |
| 3.0 |
8.6 |
12.0 |
1.6 |
What is the half-life of this antibiotic ? Calculate the CLT if the AUC was 72 mg-hr/L, and calculate the Vd of this drug.
Identify the linear portion
of the curve that
represents drug elimination
Calculate k or the half-
life from the line
t1/2
Graphically t1/2 = 3hr
CLT =
(1) 500 mg
72 mg-hr/L
= 6.94 L/hr
Vd =
6.94L /hr
0.693 /3hr
= 30L
