Determination of the Pharmacokinetic
Parameters (cont'd)

5- Total body clearance

The total body clearance is calculated from the administered dose, the bioavailability and the AUC according to the following relationship:

CLT =

F Dose

AUC

6- Volume of distribution

The volume of distribution is calculated from the CLT and k according to the following relationship:

CLT

Vd
= k
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