Determination of the Pharmacokinetic
Parameters (cont'd)

4- Bioavailability

The bioavailability is determined by comparing the AUC calculated after iv and after oral administration of the same drug.

After a single iv drug administration:

AUCiv =

Fiv Dose

CLT

- After a single oral drug administration:

AUCoral =

Foral Dose

CLT

When the iv and oral doses are equal and because the bioavailability after iv is 100% :

F =

AUCoral

AUCiv
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