Effect of the pharmacokinetic parameters on the drug distribution between the central and peripheral compartments (Cont'd)
c - First-order transfer rate constant, k10
Examine the drug amount-time profiles in the central and peripheral compartments after a single iv administration of the same dose when only k10 is different.
The ratio of the AUC in the central and peripheral compartments is constant, however this ratio may look different because of the semilog scale.
Detailed conclusion
Drugs with larger k10 have faster distribution rate and faster elimination rate, however the peripheral to central distribution ratio remains constant.
k12is the first-order transfer rate constant from the central to the peripheral compartment (time-1).
k21is the first-order transfer rate constant from the peripheral to the central compartment (time-1).
k10is the first-order elimination rate constant (time-1).
k10
- Larger k10 leads to faster distribution rate, elimination rate and higher total body clearance. This leads to smaller AUC in the central compartment.
- The change in k10 does not affect the intercompartmental clearance ratio between the peripheral compartment and the central compartment.
- The change in k10 does not affect the peripheral to central distribution ratio.
