Effect of the pharmacokinetic parameters
on the drug distribution between the central
and peripheral compartments

a- Dose

Examine the drug amount-time profiles in the central and peripheral compartments after iv administration of different doses. All other parameters are constant.

Parameters
D(mg) k12 (hr-1) k21 (hr-1) k10 (hr-1)
800 .22 .2 .35
Dose (mg)

Detailed conclusion

Administration of different doses do not affect the distribution ratio between the central and peripheral compartments.