Administration of different doses of the same drug will result in a proportional change in the amount of the drug in the central and peripheral compartments. However the distribution ratio between the compartments remains constant.
Dose (mg)
Changing the dose does not affect the drug
distribution ratio between the central and
peripheral compartments.
b- First-order transfer rate constant, k12
The change in k12 will change the steady state central to peripheral drug distribution ratio. The average amount of the drug in the central compartment does not change (because the CLT does not change) but the average drug amount in the peripheral compartment increases due to the increase in k12
k12 (hr-1)
The ratio of the amount of the drug, in the
central compartment to the amount of the
drug, in the peripheral compartment at s.s is
dependent on the ratio of k21 to k12.
k21 = 0.3 hr -1
k10 = 0.08 hr -1
