c- First-order transfer rate constant, k21
The change in k21 will affect the steady state central to peripheral drug distribution ratio. The average amount of the drug in the central compartment does not change (the CLT does not change) but the average amount in the peripheral compartment decreases due to the increase in k21.
k12 = 0.3 hr -1
k10 = 0.08 hr -1
k21 (hr-1)
The ratio of the amount of the drug, in the
central compartment to the amount of the
drug in the peripheral compartment at s.s is
dependent on the ratio of k21 to k12.
d- First-order elimination rate constant, k10
The change in k10 will change the amount of the drug in the central and the peripheral compartments. However the steady state central to peripheral drug distribution ratio will not change.
k12 = 0.35 hr -1
k21 = 0.3 hr -1
k10 (hr-1)
The ratio of the amount of the drug, in the
central compartment to the amount of the
drug in the peripheral compartment at s.s is
dependent on the ratio of k21 to k12.
